Kafukufuku watsopano wochokera ku yunivesite ya Connecticut ku United States amakonda kutsimikizira kuti ndudu zamagetsi ndi zovulaza mofanana ndi ndudu wamba. Ndizowonongeka kwambiri chifukwa cha nthunzi ya ndudu ya e-fodya pa DNA yomwe ikuwonetsedwa ndi akatswiri a sayansi ya yunivesite.
Ndudu wa E-Cigarette Imadzetsa ZINTHU ZOWONONGA KWAMBIRI KWA DNA NGATI Ndudu POpanda ZOSEFA
Kafukufuku wopangidwa ndi akatswiri a zamankhwala ku yunivesite ya Connecticut angapereke umboni watsopano wakuti ndudu zamagetsi zimakhala zovulaza monga ndudu wamba. Pogwiritsa ntchito chipangizo chatsopano chamitundu itatu, ofufuza a UConn adapeza kuti ndudu za e-fodya zodzaza ndi nicotine e-liquid zitha kukhala zovulaza ngati ndudu zosasefedwa zikakhudza kuwonongeka kwa thupi.
Ofufuzawo adapezanso kuti nthunzi yochokera ku ndudu ya e-fodya yokhala ndi e-liquid yopanda chikonga idawononga kwambiri DNA monga ndudu yokhala ndi zosefera. Chifukwa cha zinthu zambiri zomwe zimapezeka mu nthunzi, kusintha kwa maselo chifukwa cha kuwonongeka kwa DNA kungayambitse khansa. Zotsatira za phunziroli zidasindikizidwa mu nyuzipepala ya ACS Sensors.
malinga ndi Karteek Kadimisetty, wofufuza wa postdoctoral mu Dipatimenti ya Chemistry ku UConn komanso mlembi wamkulu wa phunziroli " Kuwonongeka kwa DNA kumadalira kuchuluka kwa nthunzi yomwe munthu amakokera, zowonjezera zina zomwe zilipo, kaya ndi chikonga kapena popanda chikonga, ndi zinthu zina.".
Koma malinga ndi iye, mapeto ake ndi omveka bwino: Kutengera zotsatira za kafukufuku wathu, titha kunena kuti ndudu za e-fodya zimatha kuwononga kwambiri DNA monga ndudu wamba wosasefera.".
Asayansi a UConn adatsimikiza kuti ngati mankhwala omwe ali mu ndudu za e-fodya angawononge DNA ya munthu poyesa chipangizo chatsopano cha electro-optical screening chopangidwa mu labu yawo. Malinga ndi ochita kafukufuku, kachipangizo kakang'ono ka 3-D kamene kamasindikizidwa akukhulupilira kuti ndicho choyamba chamtundu wake chomwe chimatha kuzindikira mwamsanga kuwonongeka kwa DNA, kapena genotoxicity, mu zitsanzo zachilengedwe m'munda.
Chipangizochi chimagwiritsa ntchito ma micropump kukankhira zitsanzo zamadzimadzi kudzera mu "ma microwell" angapo ophatikizidwa mu kachipu kakang'ono ka kaboni. Zitsime zimadzazidwa ndi ma enzymes a metabolic amunthu komanso DNA. Zitsanzo zikagwera m'zitsime, ma metabolites atsopano omwe angayambitse kuwonongeka kwa DNA amapangidwa. Zomwe zimachitika pakati pa metabolites ndi DNA zimapanga kuwala kojambulidwa ndi kamera. Mkati mwa mphindi zisanu, ogwiritsa ntchito amatha kuona kuwonongeka kwa DNA yaumunthu.
chifukwa Karteek Kadimisetty : “ Chipangizocho ndi chapadera, chimasintha mankhwala kukhala metabolites awo panthawi yoyesedwa, izi ndizomwe zimachitika m'thupi la munthu. »
Ma bioassays omwe amagwiritsidwa ntchito pano kuti adziwe kuchuluka kwa ma genotoxicity a zitsanzo zachilengedwe atha kukhala ochulukirapo, koma nthawi zambiri amatenga nthawi komanso okwera mtengo. Zida za labu zokha zimawononga madola masauzande ambiri. Matrix
opangidwa ku UConn amapereka chida chofunikira choyamba chowunikira cha genotoxicity mumphindi zochepa. Ndipo chifukwa cha kupita patsogolo kwaposachedwa pakusindikiza kwa 3-D, chip core cha chipangizochi chimatha kutayidwa ndipo chimangotengera dola imodzi kupanga.
Pakafukufuku wapano, ofufuzawo adatenga zitsanzo za nthunzi ndi utsi pogwiritsa ntchito njira yopangira inhalation. Nduduzo zinalumikizidwa ndi chubu chomwe chinali ndi pulagi ya thonje. Kenako ofufuzawo adagwiritsa ntchito syringe kumbali ina ya chubu kutsanzira inhalation. Choncho zitsanzo zimachokera ku mankhwala ogwidwa mu thonje.
Gululo linatenga zitsanzo pambuyo pa 20, 60 ndi 100 puffs. Malinga ndi Karteek Kadimisetty , Kuwonongeka kwa DNA komwe kumachitika chifukwa cha ndudu za e-fodya kunawonjezeka ndi kuchuluka kwa kukoka. " Anthu ena amavape kwambiri chifukwa amaganiza kuti palibe zoopsa.", akutero. " Tinkafuna kuwona zomwe zingachite ku DNA, ndipo tinali ndi zida za labu kuti tichite.“. Kwa ofufuza, Pali mazana a mankhwala mu ndudu za e-fodya zomwe zingapangitse kuwonongeka kwa DNA".
Kafukufukuyu adathandizidwa ndi ndalama zochokera ku National Institute of Environmental Health Sciences ya National Institutes of Health.
gwero Chithunzi: Eurekalert.org
Kuyamikira zithunzi : Karteek Kadimisetty / ACS Sensors. Copyright 2017 American Chemical Society.
