Nanga bwanji ngati metformin, yomwe ndi mankhwala oletsa matenda a shuga, ingachepetse zizindikiro za kusiya chikonga n’kuthandiza kuti asiye kusuta? Mulimonsemo, izi ndi zomwe kafukufuku waposachedwapa akusonyeza.
KODI METFORMIN NDIYOTHANDIZA KUPOSA MALOWA NICOTINE?
Kafukufuku wa mbewa (wowerengedwa mu Proceedings of the American Academy of Sciences) akusonyeza kuti metformin, mankhwala odziwika bwino a matenda a shuga a mtundu wachiwiri, amatha kuthetsa zizindikiro za kusiya chikonga.
Kukumana ndi chikonga kwa nthawi yayitali kumayambitsa puloteni yotchedwa AMPK, yomwe ili m'dera la hippocampus ndipo imakhudzidwa ndi kukumbukira ndi kutengeka maganizo. Zasonyezedwa kale kuti kutsegula kwa njira ya mankhwala ya AMPK kungathandize kuti mukhale ndi moyo wautali wautali, ndikulimbikitsa kukumbukira ndi kulingalira. Makhalidwe amenewa mwangozi ndipo kawirikawiri amatsatira mchitidwe wosuta ndudu.
Kusiya chikonga kumaletsa kukondoweza kumeneku, komwe kungayambitse kukhumudwa, kukwiya, ndi kulephera kumvetsera ndi kukumbukira. Kusiya kusuta kumatanthauza kuyimitsa kuyambitsa kwa enzyme AMPK (AMP-activated protein kinase), kutanthauza kuti kuyambitsa zizindikiro zosiya, zomwe zimapezeka mwa osuta ambiri. Popeza metformin idalembedwa kale kuti iyambitse AMPK, ofufuza a University of Pennsylvania ndi Johns Hopkins University adadabwa ngati metformin ingalipire kuchotsedwa kwa chikonga mwadzidzidzi.
Kafukufukuyu adapeza kuti mbewa zokhala ndi chikonga zoperekedwa jakisoni wa metformin asanamuyamwitse zimawonetsa kutsika kwa nkhawa, monga momwe amawonera ndikudya kwawo komanso kuyesa kwa zochitika.
Ngati sitiri mbewa, zotsatira zoyamba izi zimachokera ku njira yachilengedwe yomwe imagwirizanitsa, kukonzanso njira yamankhwala ya AMPK iyi. Mpaka pano, a 
Metformin imaloledwa kokha kuchiza matenda a shuga, kotero palibe kukayikira kuigwiritsa ntchito kuti muchepetse zizindikiro za kusiya kusuta. Komabe, zotsatira zoyambazi zimayenera kufufuza kwina, kuti zitsimikizidwe kuti zimagwira ntchito bwino posiya kusuta komanso kuti zimakhala zopambana kuposa zomwe zilipo kale za chikonga. Olembawo analemba kuti:
Kutengera zotsatira zathu zomwe zikuwonetsa mphamvu ya metformin pochepetsa nkhawa pambuyo pochotsa chikonga, tikuwonetsa kuti kuyambitsa kwa AMPK muubongo kudzera pa metformin kumatha kuonedwa ngati njira yatsopano yopangira mankhwala kuti asiye kusuta. Metformin imayenera kufufuzidwa ngati njira yochizira pakusiya kusuta, m'mayesero azachipatala amtsogolo, makamaka popeza mankhwalawa ndi otetezeka komanso phindu lowonjezera la kuwongolera shuga wamagazi.
gwero : Santelog.com/
