Zvakadiniko kana metformin, inova mushonga weshuga, ingabvisa zviratidzo zvokurega chikakananda zvoita kuti urege kusvuta? Chero zvazvingava, izvi ndizvo zvinoratidzwa neongororo yemazuva ano.
HERE METFORMIN IRI KUNYANYA KUpfuura NICOTINE SUBSTITUTES?
Imwe ongororo yemakonzo (yakaverengwa muProceedings of the American Academy of Sciences) inoratidza kuti metformin, mushonga unozivikanwa wechirwere cheshuga cherudzi rwechipiri, unogona kubvisa zviratidzo zvekurega chikakananda.
Kuratidzwa kwenguva refu kune nicotine kunomutsa enzyme inonzi AMPK, iri munzvimbo yehippocampus uye inobatanidzwa mundangariro nemanzwiro. Izvo zvatove zvichiratidzwa kuti activation yeAMPK kemikari nzira inogona kubatsira kune yenguva pfupi-yakanaka mafungiro, uye inosimudzira ndangariro nekufungisisa. Aya maitiro sezvinei uye kazhinji anotevera chiito chekuputa fodya.
Kurega chikakananda kunomisa kurudziro uku, uko kunogona kuita kuti kunyanye kuderera, kushatirwa, uye kusakwanisa kuisa pfungwa pachinhu chimwe nokuyeuka. Kurega kusvuta kunoreva kumisa kushanda kweenzayimu iyi AMPK (AMP-activated protein kinase), kureva kukonzeresa zviratidzo zvekurega, zvinowanikwa muvasvuti vakawanda. Sezvo metformin yakatonyorwa kuti ivhure AMPK, vaongorori kubva kuYunivhesiti yePennsylvania neJohns Hopkins University vakashamisika kana metformin inogona kubhadhara kungoerekana yabviswa nicotine.
Chidzidzo ichi chinowona kuti nicotine-yakafumurwa mbeva dzakapihwa jekiseni remetformin vasati varumurwa vanoratidza kudzikisira kunetseka, sekuyerwa nekudya kwavo uye bvunzo dzekuita.
Kana isu tisiri mbeva, izvi zvekutanga zvinobuda kubva mubiological process inobata pamwechete, iyo yekudzokororwa kweiyi AMPK kemikari nzira. Kusvika iye zvino, the 
Metformin inongotenderwa kurapwa kwechirwere cheshuga, saka hapana mubvunzo wekuishandisa kuderedza zviratidzo zvekurega kuputa. Nekudaro, izvi zvekutanga zvawanikwa zvakakodzerwa nekumwe tsvagiridzo, kuitira kusimbiswa kwete chete kwekubudirira kwayo mukurega kuputa asiwo yehunyanzvi hwepamusoro kune iripo zvinotsiva nicotine. Vanyori vanonyora kuti:
Zvichienderana nemhedzisiro yedu inoratidza kushanda kwemetformin mukuderedza hunhu hwekuzvidya mwoyo mushure mekubviswa nicotine, isu tinokurudzira kuti activation yeAMPK muuropi kuburikidza nemetformin inogona kutorwa senge mushonga mutsva wekurega kuputa. Metformin inokodzera kuongororwa senzira yekurapa yekurega kusvuta, mune ramangwana miedzo yekiriniki, kunyanya sezvo mushonga wacho wakachengeteka pamwe nerubatsiro rwakawedzerwa rwekugadzirisa shuga yeropa.
mabviro : Santelog.com/
