Iiyure ezintandathu zokuvezwa komsi wecuba zibangele ukufa okuphantse kuphelele kweeseli ezivavanyiweyo, ngelixa ukuvezwa okufanayo kwi-e-cigarette vapor akuzange konakalise ukusebenza kwezicubu.
Ukuvavanya usebenzisa iintlobo ezimbini ezahlukeneyo ze-e-cigarettes, umphunga oveliswayo wawungenayo impembelelo ye-cytotoxic kwizicubu zokuphefumula komntu, ngokutsho kophando olutsha olupapashwe kwi-In Vitro Toxicology (DOI: 10.1016 / j.tiv .2015.05.018).
Izazinzulu ze I-British American Tobacco et Inkampani yeMatTek isebenzise indibaniselwano ekhethekileyo yovavanyo lokufunda iziphumo ezibi ezinokubakho zomphunga we-e-cigarette kwizicubu zomoya kwaye uthelekise nomsi wecuba. “Ukusebenzisa umatshini womsi kunye novavanyo olusekelwe kwilebhu usebenzisa izicubu zokuphefumla, kwakunokwenzeka ukulinganisa umthamo ocaphukisayo we-aerosol kwaye ubonise ukuba i-aerosols eyahlukileyo ekhoyo kwi-e-cigarette esetyenziswe kolu phando ayinayo impembelelo ye-cytotoxic kwiithishu zendlela yokuphefumla. abantu ", satsho isithethi UGqr Marina Murphy.
Le ndlela intsha ingasetyenziselwa ukunceda ukuphuhlisa imigangatho emitsha kwezi ntlobo zeemveliso kwixesha elizayo.
Umphunga oveliswa yi-e-cigarettes unokuba ne-nicotine, i-humectants, i-flavour kunye neemveliso zokuthotywa kwe-thermal, ngoko ke kubalulekile ukuqonda impembelelo enokubakho kwiinkqubo zebhayoloji. Ukuthi ga, akukhange kubekho zifundo ezibonisa iziphumo ezibi ezinokubakho zomphunga we-e-cigarette kwiimodeli ezisetyenziswa kwi-vitro ezilinganisa ngokugqibeleleyo isakhiwo, umsebenzi kunye nokuvezwa kwezicubu eziqhelekileyo zokuphefumla komntu.
Abaphandi badibanisa imodeli ye-3D yezicubu ze-epithelial zokuphefumula ezithengiswayo kunye ne-robot "Vitrocell" ngokuqhelekileyo isetyenziselwa olu hlobo lovavanyo "ngomsi" ukwenzela ukuvavanya amandla okucasula kwe-e-cigarette vapor yeemodeli ezimbini ezikhoyo zorhwebo. Iziphumo zibonisa ukuba, nangona iiyure zokuvezwa ngokuqhubekayo, impembelelo ye-e-cigarette vapor kwi-airway tissue ifana neyomoya. Ukongezelela, isifundo simele inyathelo lokuqala elibhekiselele kwintlalontle kwaye liqalise ingxoxo malunga nezikhokelo ezinokubakho kwishishini.
Imodeli yethishu yomoya EpiAirway »iquka iiseli ze-tracheal/bronchial epithelial eziye zakhuliswa ukuze zenze iileya ezahlukeneyo ezifana nezicubu ze-epithelial zendlela yokuphefumla. Inkqubo " Vitrocell » ilinganisa ukuvezwa kwesixhobo sokuphefumlela umntu ngokubonelela ngedatha ngezinto ezikhutshwayo eziveliswa ngumdiza okanye i-e-cigarettes. Inokubuyisela ngokulula ukuphefumla kwiithishu. EpiAirway".
Abaphandi baqale bavavanya inkqubo yebhayoloji ngezinto ezicaphukisayo ezaziwayo ezifakwe kulwelo. Emva koko bawatyhila amalaphu EpiAirway kumsi wecuba kunye ne-aerosols eyenziwe kwiintlobo ezimbini ze-e-
icuba iiyure ezintandathu. Ngeli xesha, ukusebenza kweeseli kwalinganiswa iyure nganye kusetyenziswa uvavanyo lwemibala. Ubungakanani be-particle mass efakwe kwi-cell surface nayo yalinganiswa (usebenzisa izixhobo ze-dosimetry) ukubonisa ukuba umsi okanye umphunga ufikelele kwi-tissue ngexesha lonke lokuvezwa.
Iziphumo zibonisa ukuba i Umsi wecuba unciphisa ukusebenza kweeseli ukuya kwi-12% (kufutshane nokufa kweeseli ngokupheleleyo) emva kweeyure ezintandathu. Ngokwahlukileyo koko, akukho nanye ye-e-cigarette aerosols ebonise ukuhla okubonakalayo ekusebenzeni kweeseli. Nangona iiyure ze-6 zokuvezwa okuqhubekayo, iziphumo zazifana nezo zeseli zokulawula ezivezwe emoyeni kuphela . Kwaye nangokuvezwa okunamandla, umphunga we-e-cigarette awunciphisi ukusebenza kweeseli.
«Okwangoku, akukho migangatho yovavanyo lwe-in vitro ye-e-cigarette aerosols ", utsho uMarina Trani, intloko ye-R&D kwimveliso ye-nicotine yaseBritani yaseMelika kwisizukulwana esilandelayo. Kodwa, wongeza, "Iprothokholi yethu inokungqina iluncedo kakhulu ekuncedeni inkqubo iqhubele phambili.»
Olu phononongo lubonisa ukuba, kule modeli yethishu yokuphefumla yomntu, i-cytotoxicity ayichatshazelwa zii-aerosols ze-e-cigarette, kodwa uphando olongezelelweyo luya kufuneka ukuthelekisa iziphumo zezinye iifomathi zemveliso ekhoyo yorhwebo.
imvelaphi : Eurekalert.org
