Kuthekani ukuba i-metformin, esiyeyathomalalisa isifo seswekile, inokuphelisa iimpawu zokuyeka inikotini ize ngaloo ndlela ibe negalelo ekuyekeni ukutshaya? Kuyo nayiphi na imeko, oku koko uphando olutshanje lucebisa.
INGABA I-METFORMIN ISEBENZA NGAPHEZU KWE-NICOTINE ENDAWENI YENICOTINE?
Uphononongo kwiimpuku (ezifundwe kwiiNkqubo ze-American Academy of Sciences) zibonisa ukuba i-metformin, ichiza elaziwayo lohlobo lwe-2 yeswekile, inokuphelisa iimpawu zokuhoxiswa kwe-nicotine.
Ukubonakaliswa kwexesha elide kwi-nicotine kusebenze i-enzyme ebizwa ngokuba yi-AMPK, ebekwe kwindawo ye-hippocampus kwaye ibandakanyeka kwimemori kunye neemvakalelo. Sele kubonisiwe ukuba ukusetyenziswa kwendlela yeekhemikhali ze-AMPK kunokufaka isandla kwimo ehlala ixesha elifutshane, kwaye kukhulise inkumbulo kunye nokugxila. Ezi mpawu ngokuzenzekelayo kwaye ngokubanzi zilandela isenzo sokutshaya icuba.
Ukuyeka inikotini kunqanda oku kuvuselelwa, okunokuthi kube negalelo kwimvakalelo ephantsi, ukucaphuka, kunye nokuphazamiseka kokungakwazi ukunikela ingqalelo nokukhumbula. Ukuyeka ukutshaya kuthetha ukuyeka ukusebenza kwale enzyme ye-AMPK (i-AMP-activated protein kinase), oko kukuthi ukubangela iimpawu zokuyeka, ezikhoyo kuninzi lwabantu abatshayayo. Ekubeni i-metformin sele ibhalwe ukuba isebenze i-AMPK, abaphandi abavela kwiYunivesithi yasePennsylvania kunye neYunivesithi yaseJohns Hopkins bazibuza ukuba i-metformin inokubuyisela ukurhoxiswa kwe-nicotine ngokukhawuleza.
Uphononongo lufumanisa ukuba iimpuku ezivezwe inikotini ezinikwe inaliti ye-metformin ngaphambi kokuba zilunyulwe zibonise ukuxhalaba okuncitshisiweyo, njengoko kulinganiswe ngokutya kwazo kunye novavanyo lomsebenzi.
Ukuba asizizo iimpuku, ezi ziphumo zokuqala ziphuma kwinkqubo yebhayoloji ebambeneyo, eyokuphinda isebenze le ndlela yekhemikhali ye-AMPK. Ukuza kuthi ga ngoku, i 
I-Metformin igunyaziswe kuphela kunyango lwesifo sikashukela, ngoko akukho mbuzo wokuyisebenzisa ukunciphisa iimpawu zokuyeka ukutshaya. Nangona kunjalo, ezi ziphumo zokuqala zifanelwe uphando olongezelelweyo, ukwenzela ukuqinisekiswa kungekhona nje kuphela ukusebenza kwayo ekuyekeni ukutshaya kodwa kunye nokusebenza okungaphezulu kwezinto ezithatha indawo ze-nicotine. Ababhali babhala:
Ngokusekwe kwiziphumo zethu ezibonisa ukusebenza kwe-metformin ekudambiseni ixhala lokuziphatha emva kokurhoxa nicotine, sicebisa ukuba ukusebenza kwe-AMPK kwingqondo nge-metformin kunokuthathwa njengonyango olutsha lonyango lokuyeka ukutshaya. I-Metformin ifanele ukuphononongwa njengendlela yonyango yokuyeka ukutshaya, kulingo lwezonyango lwexesha elizayo, ngakumbi njengoko ichiza likhuselekile nokongezwa kwenzuzo yokulawula iswekile yegazi njengesiqhelo.
imvelaphi : Santelog.com/
