Ucwaningo olusha oluvela eNyuvesi yaseConnecticut e-United States luvame ukufakazela ukuthi ugwayi we-electronic uyingozi njengogwayi ovamile. Iwona kanye umonakalo odalwe wumusi kagwayi we-elekthronikhi ku-DNA okhonjwa ngosokhemisi baseNyuvesi.
I-E-CIGARETTE IBANGA UMONAKALO OMUNINGI KU-DNA NJENGOSIGARETHI NGAPHANDLE KWEZIHLUNGI
Ngakho-ke ucwaningo olwenziwa osokhemisi eNyuvesi yaseConnecticut lunganikeza ubufakazi obusha bokuthi ugwayi we-electronic uyingozi njengogwayi ovamile. Besebenzisa idivayisi entsha yokuhlola ephrintiwe enezinhlangothi ezintathu, abacwaningi be-UConn bathole ukuthi ama-e-cigarettes alayishwe i-nicotine e-liquid ayengaba yingozi njengogwayi ongahlungiwe uma kuziwa ekulimaleni komzimba. I-DNA.
Abacwaningi baphinde bathola ukuthi umhwamuko ophuma ku-e-cigarettes one-e-liquid engena-nicotine ubangele umonakalo omkhulu we-DNA njengogwayi onezihlungi. Ngenxa yezithasiselo zamakhemikhali eziningi ezikhona emhwamukeni, ukuguqulwa kwamangqamuzana okubangelwa ukulimala kwe-DNA kungaholela kumdlavuza. Imiphumela yalolu cwaningo yanyatheliswa kumagazini i-ACS Sensors.
ngokusho UKarteek Kadimisetty, umcwaningi we-postdoctoral eMnyangweni Wezekhemikhali e-UConn nombhali oholayo wocwaningo” Ukulimala kwe-DNA kuncike enanini lomhwamuko ohogelwe umsebenzisi, ezinye izithasiselo ezikhona, kungaba nge-nicotine noma ngaphandle kwayo, nezinye izici.".
Kodwa ngokusho kwakhe, isiphetho sicace kakhulu: Ngokusekelwe emiphumeleni yocwaningo lwethu, singaphetha ngokuthi ugwayi we-electronic unamandla okubangela umonakalo omkhulu we-DNA njengogwayi ovamile ongahlungiwe.".
Ososayensi be-UConn bazimisele ukunquma ukuthi amakhemikhali ku-e-cigarettes angayilimaza yini i-DNA yomuntu ngokuhlola idivayisi entsha yokuhlola i-electro-optical eyenziwe elebhu yabo. Ngokusho kwabacwaningi, idivayisi encane ephrintiwe ye-3-D kukholakala ukuthi ingeyokuqala yohlobo lwayo ekwazi ukubona ngokushesha umonakalo we-DNA, noma i-genotoxicity, kumasampula emvelo emkhakheni.
Idivayisi isebenzisa amaphampu amancane ukuze iphushe amasampula oketshezi ngokusebenzisa "ama-microwell" amaningi ashumekwe ku-carbon chip encane. Imithombo ilayishwa ngaphambilini ngama-enzymes we-metabolic womuntu asebenzayo kanye ne-DNA. Njengoba amasampula ewela emithonjeni, ama-metabolite amasha angabangela ukulimala kwe-DNA ayakhiwa. Ukusabela phakathi kwama-metabolites ne-DNA kukhiqiza ukukhanya okuthathwe yikhamera. Phakathi nemizuzu emihlanu, abasebenzisi bangabona umonakalo ku-DNA yomuntu.
ngoba UKarteek Kadimisetty : “ Idivayisi ihlukile, iguqula amakhemikhali abe ama-metabolites awo ngesikhathi sokuhlolwa, yilokhu kanye okwenzeka emzimbeni womuntu. »
Ama-Bioassays okwamanje asetshenziselwa ukunquma ubuthi be-genotoxicity wamasampuli emvelo angase aphelele, kodwa ngokuvamile adla isikhathi futhi abizayo. Imishini yelebhu iyodwa ibiza amashumi ezinkulungwane zamaRandi. I-matrix
ithuthukiswe e-UConn inikeza ithuluzi lokuhlola elibalulekile lokuqala le-genotoxicity ngemizuzu nje. Futhi ngenxa yentuthuko yakamuva yokuphrinta kwe-3-D, i-chip eyinhloko yedivayisi iyalahlwa futhi kubiza idola nje ukuyenza.
Ocwaningweni lwamanje, abacwaningi bathathe amasampula omhwamuko nentuthu besebenzisa indlela yokuhogela yokwenziwa. Ugwayi wawuxhunywe eshubhuni elalinepulaki likakotini. Abacwaningi babe sebesebenzisa isirinji ngakolunye uhlangothi lweshubhu ukulingisa ukuhogela. Ngakho-ke amasampula avela kumakhemikhali athathwe ukotini.
Ithimba liqoqe amasampula ngemuva kokuphafuza okungu-20, 60 no-100. Ngokusho UKarteek Kadimisetty , Umonakalo ongaba khona we-DNA obangelwa ugwayi we-elekthronikhi wanda ngenani lokudonsa. " Abanye abantu ba-vape kakhulu ngoba becabanga ukuthi azikho izingozi.“, uyachaza. " Besifuna ukubona ukuthi empeleni ingenzani ku-DNA, futhi sinezinsiza zelebhu zokukwenza.“. Okomcwaningi, Kunamakhulu amakhemikhali ku-e-cigarettes angaba nomthelela ekulimaleni kwe-DNA".
Ucwaningo lusekelwe yizimali ezivela ku-National Institute of Environmental Health Sciences of the National Institutes of Health.
Umthombo : Eurekalert.org
Amakhredithi esithombe : Izinzwa ze-Karteek Kadimisetty / ACS. Copyright 2017 American Chemical Society.
