Kuthiwani uma i-metformin, engumuthi wokunqanda isifo sikashukela, ingadambisa izimpawu zokuyeka i-nicotine futhi ngaleyo ndlela ibe nomthelela ekuyekeni ukubhema? Kunoma yikuphi, yilokhu okushiwo ucwaningo lwakamuva.
INGABE I-METFORMIN ISEBENZA KAKHULU KUNE-NICOTINE SUBSTITUTE?
Ucwaningo olwenziwa kumagundane (olufundwa kuyi- Proceedings of the American Academy of Sciences) lusikisela ukuthi i-metformin, umuthi owaziwayo wohlobo 2 lwesifo sikashukela, ingadambisa izimpawu zokuhoxiswa kwe-nicotine.
Ukuchayeka ku-nicotine isikhathi eside kwenza i-enzyme ebizwa ngokuthi i-AMPK, etholakala endaweni ye-hippocampus futhi ebandakanyeka enkumbulo nemizwelo. Sekuvele kubonisiwe ukuthi ukusebenza kwendlela yamakhemikhali ye-AMPK kungaba nomthelela esimweni esihle sesikhashana, futhi kukhulise inkumbulo nokugxila. Lezi zici ngokuzenzekelayo futhi ngokuvamile zilandela isenzo sokubhema ugwayi.
Ukuyeka i-nicotine kumisa lokhu kushukumisa, okungase kube nomthelela ekushintsheni kwemizwa, ukucasuka, nekhono elikhubazekile lokugxilisa ingqondo nokukhumbula. Ukuyeka ukubhema kusho ukumisa ukusebenza kwale enzyme AMPK (AMP-activated protein kinase), okusho ukuthi kubangela izimpawu zokuyeka, ezikhona kubantu abaningi ababhemayo. Njengoba i-metformin isivele ibhaliwe ukuze iqalise i-AMPK, abacwaningi baseNyuvesi yasePennsylvania naseJohns Hopkins University bazibuza ukuthi ingabe i-metformin ingakwazi yini ukunxephezela ukuhoxa kungazelelwe nicotine.
Ucwaningo luthola ukuthi amagundane aveze i-nicotine anikezwe umjovo we-metformin ngaphambi kokulunyulwa abonisa ukukhathazeka okuncishisiwe, njengoba kukalwa ngokudla kwawo kanye nokuhlolwa komsebenzi.
Uma singewona amagundane, le miphumela yokuqala iphuma kunqubo yebhayoloji ebambana ndawonye, leyo yokuphinda isebenze le ndlela yamakhemikhali ye-AMPK. Kuze kube manje, i- 
I-Metformin igunyazwe kuphela ekwelapheni isifo sikashukela, ngakho-ke akukho mbuzo wokuyisebenzisa ukwehlisa izimpawu zokuyeka ukubhema. Kodwa-ke, le miphumela yokuqala idinga ucwaningo olwengeziwe, ukuze kuqinisekiswe ukuthi ingagcini nje ngokuphumelela kwayo ekuyekeni ukubhema kodwa futhi nempumelelo ephakeme kunezinye ezikhona esikhundleni se-nicotine. Ababhali babhala:
Ngokusekelwe emiphumeleni yethu ebonisa ukusebenza kahle kwe-metformin ekudambiseni ukuziphatha kokukhathazeka ngemva kokuhoxiswa kwe-nicotine, siphakamisa ukuthi ukwenziwa kusebenze kwe-AMPK ebuchosheni nge-metformin kungase kubhekwe njengendlela yokwelapha entsha yemithi yokuyeka ukubhema. I-Metformin ifanele ukubhekwa njengendlela yokwelapha yokuyeka ukubhema, ezivivinyweni zomtholampilo ezizayo, ikakhulukazi njengoba umuthi uphephile uma uqhathaniswa nenzuzo eyengeziwe yokulawula ushukela wegazi ngendlela evamile.
Umthombo : I-Santelog.com/
